郑国栋,男,中山大学生药学博士,kok官网入口教授,博士生导师,kok官网入口生药学教研室主任。为广州市高层次人才优秀专家,广东省部企业科技特派员,广东省农业科技特派员,广东省高校优秀青年教师培养对象,kok官网入口高水平大学学术骨干培育对象,kok官网入口“千百十工程”第七批校级重点培养对象,ACS收录杂志Journal of agricultural and food chemistry(SCI)、John Wiley收录杂志Phytochemical analysis(SCI)等杂志审稿人。目前专注于中药资源开发利用、天然产物活性成分、提取物及其质量控制研究。
近来尤其是在道地药材广陈皮活性成分、质量控制方法及资源开发利用进行了较为系统的研究,被聘为新会陈皮国家现代农业产业园智库首席科学家。主持陈皮方面国家重点研发计划课题1项、国家自然科学基金1项、广东省自然科学基金1项、广东省教育厅人才培养项目1项、市厅级课题3项、校企横向合作课题7项,获得资助经费五百余万元。在国内外核心期刊发表陈皮相关论文30余篇,制订行业标准2部,获授权发明专利1项。协助企业开发了新会陈皮酵素饮料等产品,年销售额过4000万元。
联系邮箱:gd200237@126.com
研究方向: 中药资源开发利用、天然产物活性成分、提取物及其质量控制研究
主要科研项目及成果
主要科研项目:1. 广陈皮生态种植基地与产地加工技术示范(国家重点研发计划“中医药现代化研究”专项子课题,2017YFC1701103,2018.01-2021.12,98万)。2. 基于“活性”指纹图谱的不同品种来源陈皮应用价值的分析与评价(国家自然科学基金青年项目,31401613,2015.01-2017.12,23万)。3. 基于效应成分物质基础的广陈皮道地性内涵及质量标准构建研究(2014年广东省高等学校优秀青年教师培养计划,粤教师函【2014】145号,2015.01-2017.12,30万)。4. 2017年kok官网入口高水平大学学术骨干培育计划(kok官网入口,广医大发 [2017]210 号,2018.01-2021.12,40万)。5. 新会陈皮存储环境与技术的研究(江门市新会区新会陈皮产业研究院,njf [2017] 110,2019.03-2019.12,75万)。6. 中国药典陈皮标准修订【xxx有限公司,HPG/2015/04/0620,2015.04-2017.12,38万】。7. 不同产地、不同年限陈皮质量分析实验研究【xxx有限公司,HPG/2015/10/1972,2016.01-2017.12,45万】。8. 新会陈皮和陈皮酵素成分检测和活性研究(xxx有限公司,2017.05-2020.5,30万)。
所获荣誉和奖励:广州市高层次人才优秀专家,广东省部企业科技特派员,广东省省级农业科技特派员,广东省高校优秀青年教师培养对象,kok官网入口高水平大学学术骨干培育对象,kok官网入口“千百十工程”第七批校级重点培养对象,新会陈皮国家现代农业产业园智库首席科学家。
主要论文及著作(代表性):
1. Zheng G D(第一作者), Liu M S, Chao Y X, Yang Y H, Zhang D D, Tao Y W, Zhang J Y, Zeng C F*, Wei M Y*. Identification of lipophilic components in Citri Reticulatae Pericarpium cultivars by supercritical CO2 fluid extraction with ultra-high-performance liquid chromatography–Q Exactive Orbitrap tandem mass spectrometry[J]. Journal of separation science, 2020, 43:3421-3440.(SCI)
2. Zheng G D(第一作者), Chao Y X, Liu M S, Yang Y H, Zhang D D, Wang K H, Tao Y W, Zhang J Y, Li Y M*, Wei M Y*. Evaluation of dynamic changes in the bioactive components in Citri Reticulatae Pericarpium (Citrus reticulata ‘Chachi’) under different harvesting and drying conditions [J]. Journal of the science of food and agriculture, 2020, DOI 10.1002/jsfa.10957(SCI)
3. Mei Z Y, Zhang R F, Zhao Z M, Xu X J, Chen B Z, Yang D P*, Zheng G D*(通讯作者). Characterization of antioxidant compounds extracted from Citrus reticulata cv. Chachiensis using UPLC-Q-TOF-MS/MS, FT-IR and scanning electron microscope [J]. Journal of Pharmaceutical and Biomedical Analysis, 2020, https://doi.org/10.1016/j.jpba.2020.113683(SCI)
4. Zheng G D(第一作者), Chao Y X, Luo M X, Xie B, Zhang D D, Hu P J, Yang X J, Yang D P*, Wei M Y*. Construction and Chemical Profile on “Activity Fingerprint” of Citri Reticulatae Pericarpium from Different Cultivars Based on HPLC-UV, LC/MS-IT-TOF, and Principal Component Analysis [J]. Evidence-Based Complementary and Alternative Medicine, 2020, Article ID 4736152, https://doi.org/10.1155/2020/4736152(SCI)
5. Zheng G D(第一作者), Yang X J, Chen B Z, Chao Y X, Hu P J, Cai Y, Wu B*, Wei M Y*. Identification and determination of chemical constituents of Citrus reticulata semen through ultra high performance liquid chromatography combined with Q Exactive Orbitrap tandem mass spectrometry [J]. Journal of separation science, 2020, 43(2): 438-451.(SCI)
6. Zheng G D(第一作者), Yang X J, Liu M S, Chao Y X, Chen B Z, Yang D P*, Wei M Y*. Supercritical CO2 Fluid Extraction for the Identification of Compounds from Citrus reticulata Semen by Ultra-High-Performance Liquid Chromatography Combined with Q-Exactive Orbitrap Tandem Mass Spectrometry [J]. ACS Omega, 2020, 5 (5) : 2180-2186.(SCI)
7. Zheng G D(第一作者), Hu P J, Chao Y X, Yang X J, Zhou Y, Chen B Z, Yu X Y*, Cai Y*. Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway [J]. Food Science & Nutrition, 2019, DOI: 10.1002/fsn3.953(SCI)
8. Gao Z, Wang Z Y, Guo Y, Chu C, Zheng G D, Liu E H*, Li F*. Enrichment of polymethoxyflavones from Citrus reticulata ‘Chachi’ peels and their hypolipidemic effect [J]. Journal of Chromatography B 2019, 1124: 226-232.(SCI)
9. Li S Z, Zeng S L, Wu Y, Zheng G D, Chu C, Yin Q, Chen B Z, Li P, Lu X, Liu E H*. Cultivar differentiation of Citri Reticulatae Pericarpium by a combination of hierarchical three-step filtering metabolomics analysis, DNA barcoding and electronic nose [J]. Analytica Chimica Acta, 2019, 1056: 62-69.(SCI)
10. Zeng S L, Li S Z, Lai C J, Wei M Y, Chen B Z, Li P, Zheng G D*(通讯作者), Liu E H*. Evaluation of anti-lipase activity and bioactive flavonoids in the Citri Reticulatae Pericarpium from different harvest time [J]. Phytomedicine, 2018, 43: 103-109. (SCI)
11. Luo M X, Luo H J, Hu P J, Yang Y T, Wu B*, Zheng G D*(通讯作者). Evaluation of chemical componentsin Citri Reticulatae Pericarpium of different cultivars collected from different regions by GC-MS and HPLC Food Science and Nutrition, 2017, DOI: 10.1002/fsn3.569. (SCI)
12. Duan L, Guo L, Dou L L, Zhou C L, Xu F G, Zheng G D, Li P*, Liu E H* Discrimination of Citrus reticulata Blanco and Citrus reticulate ‘Chachi’ by gas chromatograph-mass spectrometry based metabolomics approach [J]. Food Chemistry. 2016, 212: 123-127.(SCI)
13. Zheng G D(第一作者), Zhou P, Yang H, Li Y S, Li P, Liu E H*. Rapid resolution liquid chromatography-electrospray ionisation tandem mass spectrometry method for identification of chemical constituents in Citri Reticulatae Pericarpium [J]. Food chemistry, 2013, 136(2): 604-611.(SCI)
14. Liu E H, Zhao P, Duan L, Zheng G D, Guo L, Yang H, Li P*. Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry [J]. Food chemistry, 2013, 141(4): 3977-3983.(SCI)
15. Zheng G D(第一作者), Li K, Li Y S, Liu E H*. Fast profiling of chemical constituents in Yiqing Capsule by ultra-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry [J]. Journal of separation science, 2012, 35(1): 174-183.(SCI)
16. Zheng G D(第一作者), Yang D P, Wang D M, Zhou F, Yang X, Jiang L*. Simultaneous determination of five bioactive flavonoids in Pericarpium Citri Reticulatae from China by high-performance liquid chromatography with dual wavelength detection [J]. Journal of agricultural and food chemistry, 2009, 57(15): 6552-6557.(SCI)